Another way to look at this is via the dual factor theory too. For an advanced lifter, maybe it takes several sessions to get enough stimulus to trigger the genes for growth. So you hit a high frequency for a period of time (a few weeks usually) and then deload to allow accomodation to occur and get rebound growth.
So something like HST with some more volume for advanced. Byran told me, in personal email correspondence, that he uses about 3-6 sets per bodypart and usually gets a per session volume of 30-50 reps. In fact here are portions of our correspondence:
Bryan Haycock: I tend to do 2 exercises per body part; 3 sets of one and 2 sets of another. 15s are a little different. Many times the first week of 15s after deconditioning I will train the same body parts everyday while the weight loads are relatively light. This soon becomes too much to continue so 1 week is about as long as I do this.
Bryan Haycock: Keep in mind that with HST it is important to use “as much volume as is necessary” to elicit an adequate growth response. I offer an example on the HST website, but I also explain that a person should use whatever volume of sets/reps as they have been conditioned to perform. After all, the effectiveness of any set (or rep for that matter) is dependent on the condition of the tissue at the time the load is applied. To say that HST doesn’t induce enough fatigue is a misunderstanding of HST principles.
As far as Zatsiorsky is concerned, he speaks from a strength background. His emphasis is on fatigue because fatigue is a primary stimulus for strength gains. I/HST focus on load, not fatigue. It is the mechanical strain on the tissue itself that is the primary stimulus for hypertrophy. This is not to say that it isn’t important for a fiber to actively contract against the force of the load, it is simply stating that mechanotransduction is the primary mechanism of hypertrophy from weight training.
I also highly value Wernbom’s paper. I’ve read it thoroughly on numerous occasions. He notes that in the studies he used for his paper that growth from a workout seemed most efficient between 30-60 total reps per session…that means per muscle group. That equates to 2 sets of 15 or 3 sets of 10 on the low end. I often do 6 sets of 5 during my fives. I don’t know many who would argue that 6 sets of 5 doesn’t induce enough “fatigue”... I tend to do 5-6 sets per muscle group during the 10s as well. None of this violates any supposed HST principle. Once again, it all depends on the level of conditioning of the lifter. I have been lifting steady for over 30 years and I have to balance the minimum effective volume with the maximum risk of injury that I can afford.
Getting old isn’t good for growth.
Once again, from my experience, both in grad school, and in the gym, and examining research such as Wernbom’s I feel that it is tension, not fatigue, that is the primary stimulus for growth in adult natural lifters. Wernbom alludes to this when he mentions that high loads with very low volume (e.g. ~12-14 total reps) also lead to significant hypertrophy. This is a high-load/low fatigue situation. And there are mechanisms and pathways that have been elucidated to account for load induced hypertrophy (sans dependency on fatigue)...it’s not “magic” and there is no need to fall back on “we don’t really know how lifting weights causes muscle to grow”.
Anyway, if you are using an HST approach and you feel your weights are too light, start your 15s heavier and repeat 3 increments instead of using 6. If you feel you aren’t tired enough do another set. HST has never said there was anything magical about the number of sets and reps. They are just a way us to keep track of what we are doing in the gym from workout to workout.
I hope I’m making sense.
-bryan