Exercise Biology - The Science of Exercise,  Nutrition & building muscle

Main Menu

Muscle Memory Solved

March 17 2013

Muscle memory is what? We all know that if you lift weights and stop lifting for a few months (3-6 months), you will lose strength and muscle. However, if you start training back again, you gain the lost muscle or strength within a few weeks - as if the muscle remembers where you left off. This phenomenon is called ‘muscle memory’.

muscle memmory bodybuilders

We used to believe this is largely due to the nervous system mechanisms. The nervous system mechanisms may explain the strength gains, but it doesn’t explain how you can gain back the muscle size so quickly.

But recent studies show that we may have finally solved the mystery of muscle memory

How did they solve it?

Unlike other cells, muscle cells have more than one nucleus (probably thousands).  So why do muscles need so many nuclei? The nucleus is basically what controls the cell and since your muscles are a lot lot bigger and way more complex than other cells in the body, one or two nuclei just cannot do the job. So when your muscles get bigger, you have to add more muscle nucleus. The increase in nucleus with muscle growth has been shown in number of studies.  It has been shown that people who take steroids and people who grow muscle easily have lot more muscle nuclei than normal.

Just like muscle growth, we believed that when we lose muscle, the opposite happens - we lose some nuclei since there is no reason for the extra nuclei to sit around.  And this was supported in studies which showed as muscle shrinks in size, the number of nucleus decreases too.

Now here comes the surprise.

However, recently, studies using different animal models (denervation, unloading, synergic ablation) showed that as muscle atrophies or shrinks due to inactivity or detraining (until 3 months), there is no loss of muscle nuclei as we previously thought! As shown in the picture, the muscle size decreased by 50% (lines) but the muscle nuclie count (stained with green dye) remained the same.

muscle memmory

So what? Since now the muscle has the same number of muscle nuclei after we stopped training, it is easy to build the muscle back to its previous size. So these muscle nuclei seems to acts like ‘memory cells’. They know how much muscle you had before you stooped training.

But why did we think muscle nuclei die with muscle loss?

The recent studies used a different technique to study these nuclei.

In previous studies they were counting nuclei which belonged to the connective tissue and other cells (satellite cells). And these nuclei do die with detraining. So researchers mistakenly assumed that the muscle nuclei die with muscle loss.  But these weren’t actual muscle nuclei. The recent studies only counted the actual muscle nuclei and showed no loss .

Implications

  • Muscle memory phenomenon can be largely explained by muscles maintaining their muscle nuclei during muscle loss or detraining.
  • These results are yet to be replicated in human studies.

Reference 1
Reference 2
Reference 3

If you like it, please share it:

Related Articles

Byron Selorme | Sun March 17, 2013  

Very cool research.

Anoop | Mon March 18, 2013  

Thanks Byron for the comment. Yep it’s really cool.

This could be one reason why people who took steroids still look big even after they stopped using it years back. And the authors speculate it would be good for people to start weight training before they get old and start ‘storing’ some myonuclei. Once you start the ageing process, there is less myonuclei added even if you want.

MetroEast Beast | Mon March 18, 2013  

great article!

Bret Contreras | Tue March 19, 2013  

Great article Anoop! Funny, I saw the recent article too and it made me think up the older article (wasn’t aware of the 2008 article). Gonna share this!

Jose Antonio | Tue March 19, 2013  

Nice article.  Reminds me of my grad school days:-)

sully | Tue March 19, 2013  

Great Job again Anoop.
Beside Steriods, is there no other way to add nuclei? Glad I started training when I was younger!

Anoop | Tue March 19, 2013  

Thanks Rob.

Thanks Bret! I thought either you or Bret would have posted this before!

Thanks Jose for taking the time!

Thanks Sully. Creatine has shown to increase satellite cells proliferation and differentiation in vitro and vivo!

Bob | Mon April 15, 2013  

This might explain how Flex Wheeler was able to compete at the 2002 without the use of steroids. His genetics paired with the added nuclei through years of steroid usage was enough to make him look well above natural and place 6th (I think).

Im still not 100% sure he was completely clean, but this new research does give more credence to his claim.

Anoop | Wed April 17, 2013  

Hi Bob,

Thanks for the comment.

I am not sure about it. But if he didn’t take any or had low doses, this may explain some of it. This also explains how bodybuilders who used to compete in the drug level, get off the drugs for years and still hold enough to win natural competitions.

Patty Hartong | Fri May 03, 2013  

agree - great article! and great to be back! Patty

Anoop | Sat May 04, 2013  

Hi Patty,

Thanks! Good to see you back. Where did you vanish?

Nick Ng | Tue May 14, 2013  

Yes!! We struck gold! Thanks, Anoop.

Dimitris | Fri May 17, 2013  

I didnt work out for a couple of years ! Lost most of my muscles ! Two months after working out i regained all the muscle mass i ve lost and i am back in my good old condition! Muscles have memory ! Thank you ! Great article

Joe | Fri August 23, 2013  

It’s a great articl,it’s helpful for me to be muscular! thank you Anoop!

Shane | Sun January 05, 2014  

Whoa this is great. I had heard of this in one of Layne Norton’s videos, but this is the first article I’ve seen on it with references.

Really fascinating smile

Robin | Sat February 01, 2014  

Does this mean that since I have never exercised and my muscles are as atrophied as can be while still being functional that I need to lower my expectations as to the level of fitness I hope to achieve? I am 62.

Anoop | Sun February 02, 2014  

Good question. I don’t know how much of a difference it will make. And the best thing you can do is to start as fast as you can.

Robin | Sun February 02, 2014  

Thanks, Anoop. I spent last night scouring this site and many of your references. Today is the proverbial first day of the rest of my life. I learned so much that I have changed up my beginner’s workout program. I am going to start with those basic compound exercises rather than my former long list of isolated exercises. I still have high expectations because I redefined my goals. Thank you so much for helping me.

Anoop | Sun February 02, 2014  

Glad to hear and do register in the forums if you have specific questions. there are other folks who can contribute too.

Also look at other barriers that is holding you back.

Robin | Sun February 02, 2014  

“Other barriers”.—thank you for reminding me. I will stay on top of those and I will register in the forum. Thanks so much.

Charles Xavier | Sun June 22, 2014  

This is a fascinating read.  I took off more than 10 years from the gym, but when I was lifting I was doing substantial weight and had substantial size.  10 years afterward, I was weak as a kitten, but it didn’t take me long to build back up to my previous weights and even surpass them which was a surprise to me. I would have been happy enough to be close.  My arms are even at their biggest at 19 inches.  I have never taken any PEDs so I figured with age there was no way for me to duplicate what I did in my mid 20’s since I shouldn’t be producing as much testosterone.  I read somewhere that every human cell is replaced over 7 years.  It would be interesting to see if the results of this study still hold true over long periods of time like my lay off from the gym, and if these muscle nuclei are reproduced as the cells are replaced over time.

Bodybuilding | Sun July 06, 2014  

Muscle memory is real. Im now in my 40’s and have not worked out or taken P.E.D. In more than 15years (age 25) as a bodybuilder. Recently ive gotten to be very out of shape and high blood pressure. I always had a 6-pack until i stopped strength training in my early 30s. I just started back in the gym and in the 1st week i can still do 75-80% of my arm strength weight max and chest. My shoulders and legs seem to be the weakest. Iused to squat 405lbs for 10reps and my 1st time back in gym i could only do 135lbs for 10reps two sets.
I think muscle maturity after late 20s helps with hypertrophy and strength. I cant stress enough that if your in your 30s stay with a clean low glycemic index,high protein 1gram per lb bodyweight eating lifestyle (no dieting).
You can lose all your fat with just weight training alone but cardio in morning on an empty stomach or with an E.C.A. Stack can burn up to a couple lbs a week!
Good luck to all the old timers getting back into the gym…

Zero Kazama | Wed October 22, 2014  

“These results are yet to be replicated in human studies.” surprised

What do you think?

Smileys

NAME

EMAIL *email will never be displayed

URL (optional)

Please answer the question below:

What is the first name of the owner of exercisebiology.com

Remember my personal information

Notify me of follow-up comments?

>