This study has always indicated what I have said to people I know for years: the bottom line is a calorie deficit. While there may be some truth to the whole insulin response concept (with higher protein and fat), I really think it’s quite minimal in the grand scheme of things for weight loss.
Which Is The Best Weight-Loss Diet?
August 09 2010
The best weight loss diet is still intensely debated and there has been very few well conducted studies which looked at this issue. Is a high protein diet better, or high carb or a high fat diet the best weight loss diet?

A recent study looked to find out which is the best weight loss diet and received a lot of good attention.
What were the strengths of the best weight loss diet study?
- Large number of participants: There were 811 participants from diverse backgrounds irrespective of age, income, geography and included a large percentage of men. Obviously the largest RCT related to determine the best weight loss diet.
- High rate of retention: The people who dropped out of the study were low which was a serious problem in other weight loss studies.
- Long Duration: The best weight loss diet study lasted for 2 years which is the longest trial for randomized weight loss trial.
- Compliance accessed: Compliance was assessed by objective markers .For example, urinary nitrogen excretion was used to asses adherence to the protein intake.
- Intense Treatment: Treatment included individual and group instructional sessions to promote adherence.
What was the design of the best weight loss diet study?
Eight hundred and eleven participants were randomly assigned to four different diets:
- 20% fat, 15% protein, and 65% carbs; Low-fat,average-protein
- 20% fat, 25% protein, and 55% carbs; Low-fat, high-protein
- 40% fat, 15% protein, and 45% carbs; High Fat, Average Protein
- 40% fat, 25% protein, and 35% carbs.High Fat High Protein
All of the diets had an average calorie deficit of 750 calories from the patients’ aggregate baseline caloric intake. Participants followed the diets for two years, during which time they were also expected to engage in 90 minutes of moderate exercise each week, keep a daily food diary, fill out a Web-based tool that monitored how closely their intake adhered to their assigned diet, and attend group and individual sessions to promote adherence
What were the results of the best weight loss diet study?
All the diets were equally successful in promoting moderate weight loss and maintaining this loss for over 2 years. Weight loss averaged 3-4 years after 2 years.
Practical Recommendations
- Any diet which emphasizes calorie restriction will work and the specific amount of protein, fat or carbs of the diet does not matter.
- Diets should be tailored to the person based on their individual and cultural preferences than based on nutritional recommendations for long term success.
- Behavioral strategies maybe more important in weight loss diets than their composition.
Related Articles
Anoop | Tue August 10, 2010
Yes- “All of the diets had an average calorie deficit of 750 calories from the patients’ aggregate baseline caloric intake.”
Most of the diet study we have are short term, like a year the most. These studies won’t tell you much since people start gaining back weight after 6-12 months on any diet. This was a study which received a lot of accolades for the way it was done. And I think behavioral strategies is the key. Most diet books and diets emphasize too much on the diet composition and why the diet better than the rest.
Yes, protein blunts hunger. The problem with high protein diets though is that normal people cannot sustain it for long periods and fall back to their usual diets.People like us who can eat high protein day after day is the minority.
Anoop | Sun August 15, 2010
Hi Karky,
I think for people who has been eating a low protein or high carb diet it is hard to change their habits, at least for a few. It could be cultural or it could be environmental.
There are studies which shows how people gradually move from a high protein or a low protein or a low carb to a moderate carb after a few months. And one of the criticisms of the study was that it wasn’t a big difference in protein or carbs, so the study is not a true measure of high carbs or high protein on body composition. But other studies shows how it is almost impossible to adhere to high protein atkins like diet and people gradually gravitate towards moderate carbs and protein.
Anoop | Sun August 15, 2010
Hi Dave & Mavros,
Thanks. I do agree.
Even the insulin resistance concept only affects a segment of the population. In fact, the study quoted by fulldeplex shows that a low carb diet maybe better for people who are insulin resistant if I remember it right.
Hi Fullduplex,
Thanks for commenting. I think they had a number of group and individual sessions, and daily meal plans for 2 week block were provided. So the treatment was pretty intense.
If they had a control group with no food counting, we then could have made some conclusions about calorie counting.
And the primary outcome was weight lost and not fat loss.
Thanks for the study!
Anoop | Sun August 15, 2010
Extreme macro nutrient recommendations always fail whether it is low carbs or high protein. People find it so hard to change their habits and eating habits. People who do stick with all the recommendations are people who are really motivated. These are the people you see in the magazines who lost 100 lbs and now workout everyday and eat healthy and stuff. It’s possible, but not the norm you know. How many people can make such a change? Not many.
I think this is the problem when diet gurus say this will work. He is getting his subjects because they have gone through other diets and believe in him and his diet and are highly motivated to begin with and will stick to it. This is why studies worry so much about the selection criteria, randomizing, drop outs, and blinding of the groups. They all start at the same point.
FullDeplex | Sun August 15, 2010
I agree that it is hard (and probably unnecessary) to change macronutrient content of your diet AND to constantly eat less. This is why I like phase-shift diets and “fasting” (I never do total fasts, but do eat almost nothing for a day or two a week) when I want to drop fat.
The hardest part about diets is that they take so long. You could call it boredom, I call it torture.
Glad you like the study, Anoop!
PS:
“Weight loss averaged 3-4 years after 2 years.”
This just has to be a typo….
Anoop | Tue August 17, 2010
It is pretty clear now that weight loss after 2-4 years will be average around 3-4 kg. As usual, in the first 6 months they saw an average of 6 kg weight loss, and then subjects started gaining weight.
And mind you, the researchers were the top in their feild, the majority of the subjects were highly educated, the particpants were highly motivated (levels assessed by interview and questionnaire) and they had multiple number of group and individual sessions. And still they coulddn’t continue with weight loss or stick with the diet plans.
And I think Mavros hit the nail on the head. What we need is a community effort which might be a paradigm shift in obesity treatments. The individualistic approach is not working as we have seen again and again. The EPODE trial which began in France which is a community based trial to prevent childhood obesity is a good example.Everyone the teachers, mayor, shop owners, resturant owners, researchers were involved in making kids move around more and eat healthy. And now it being tried in other towns in Europe.
Anoop | Wed August 18, 2010
Hi Anatoly,
When it comes to overweight or obese individuals, it is mostly fat and less muscle. And muscle loss is somewhat accepted for these population.
Exercise plays a bigger role in maintaining weight lost it seems. And when the study means exercise, it is mostly walking and cardio stuff.
And I don’t know if anyone has really looked into if weight training helps for weight loss/weight maintenance or if it makes a difference to add to the cardio. Weight training has never been really popular with obesity researchers.
And the study only looked at weight and waist circumference for composition measures.
Anoop | Fri August 20, 2010
The calorie burned depends on your body weight too. So a obese or overweight person burns a lot more than lean individuals. So the calories burned is not always fixed number. This is part of the reason women find it so hard to keep losing bcos of their small BMI.
There are couple of reasons quoted for exercise helping in weight maintenance. Couple of them are: the increase in expenditure with exercise compensates for the decrease in energy expenditure due to weight loss, physical activity adherence can also improve diet adherence.
Good discussion, guys.
I did not read this article as I only need to look at the argument which we have heard a million times which is better high fat or low fat or high carbohydrate intake or low intake at the end of the day for weight loss it is how many calories you burn then you eat and the amount of any fat, carbs and protein you eat all depends on your lifestyle, training, weight loss goal etc and I personaly believe low carb diets lead to decreased energy thus less activity leading to weight gain.
Anoop | Fri October 08, 2010
Thanks for the comment BJ. I do think the researchers conducted the study because we weren’t really sure about it.
And as you said according “to your personal opinion”, Usually personal opinions are more often wrong than right.
Well from personal experience with myself and others I know Low carb diets don’t work.
mtfitness | Mon October 11, 2010
I agree. There are no 1 size fits all diets. Another thing to note is there is no such thing as a( 30 - 60 - 90 ) day diet. Fitness and proper eating habits are a life time effort.
I aggree it is what suits you some people can do it where as others can’t same with fitness the train of thought is high intense exercise burns weight fast which it does but it might not suit yourself.
Anoop | Mon August 08, 2011
Hi Toni,
I usually have the references at the end of the article. It is at the bottom of the article in blue.
Dane McGuckian | Thu January 26, 2012
Hi Anoop,
If you get a chance, I’d love to hear your thoughts on this review of research:
Low-Carbohydrate Diets Promote a More Favorable Body Composition Than Low-Fat Diets
Volek, Jeff S PhD, RD; Quann, Erin E PhD, RD; Forsythe, Cassandra E PhD, RD
Author Information
Department of Kinesiology, University of Connecticut, Storrs, Connecticut
Here is a bit of the Abstract: “A PRIMARY CONCERN WITH CONVENTIONAL WEIGHT LOSS APPROACHES IS THE LOSS OF LEAN BODY MASS THAT OCCURS WHEN FAT MASS IS DECREASED. CONSUMING MODERATE PROTEIN, WHILE RESTRICTING CARBOHYDRATE,ALLOWS FOR GREATER PRESERVATION OF LEAN BODY MASS. A LOW-CARBOHYDRATE DIET IN CONJUNCTION WITH PERIODIZED RESISTANCE TRAINING PROMOTES GREATER FAT LOSS WHILE PRESERVING LEAN BODY MASS AND
PROMOTING ROBUST IMPROVEMENTS IN METABOLIC HEALTH.”
Sincerely,
Dane

